Format

Send to

Choose Destination
Breast Cancer. 2013 Apr;20(2):174-80. doi: 10.1007/s12282-011-0322-1. Epub 2011 Dec 28.

Serum leptin level and waist-to-hip ratio (WHR) predict the overall survival of metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs).

Author information

1
Division of Medical Oncology, Selcuk University Meram Medical Faculty, Konya, Turkey. martac@selcuk.edu.tr

Abstract

INTRODUCTION:

Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs).

METHODS:

Sixty MBC patients treated with first line hormonal therapy were enrolled in this study.

RESULTS:

Median age was 51 years (range 28-75). Median leptin level was 19400 pg/ml (1970-91900) and estradiol level 29.6 pg/ml (4.0-181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was ≥19400 pg/ml (HR = 0.38; 95% CI: 0.16-0.91).

CONCLUSIONS:

This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.

PMID:
22203581
DOI:
10.1007/s12282-011-0322-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center