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Nat Rev Microbiol. 2011 Dec 28;10(2):123-36. doi: 10.1038/nrmicro2677.

From the regulation of peptidoglycan synthesis to bacterial growth and morphology.

Author information

1
Department of Microbiology & Immunology, University of California, San Francisco, USA.

Abstract

How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.

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PMID:
22203377
PMCID:
PMC5433867
DOI:
10.1038/nrmicro2677
[Indexed for MEDLINE]
Free PMC Article

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