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Biochim Biophys Acta. 2012 Jun;1817(6):965-76. doi: 10.1016/j.bbabio.2011.12.006. Epub 2011 Dec 19.

Biogenesis of inner membrane proteins in Escherichia coli.

Author information

1
Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands. joen.luirink@falw.vu.nl

Abstract

The inner membrane proteome of the model organism Escherichia coli is composed of inner membrane proteins, lipoproteins and peripherally attached soluble proteins. Our knowledge of the biogenesis of inner membrane proteins is rapidly increasing. This is in particular true for the early steps of biogenesis - protein targeting to and insertion into the membrane. However, our knowledge of inner membrane protein folding and quality control is still fragmentary. Furthering our knowledge in these areas will bring us closer to understand the biogenesis of individual inner membrane proteins in the context of the biogenesis of the inner membrane proteome of Escherichia coli as a whole. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes.

PMID:
22201544
DOI:
10.1016/j.bbabio.2011.12.006
[Indexed for MEDLINE]
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