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Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.

Dnmt3a silences hematopoietic stem cell self-renewal.

Author information

1
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA. trowbridge@bloodgroup.tch.harvard.edu

Abstract

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

PMID:
22200773
DOI:
10.1038/ng.1043
[Indexed for MEDLINE]

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