Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Genet. 2011 Dec 27;44(1):11-3. doi: 10.1038/ng.1048.

Following evolution of bacterial antibiotic resistance in real time.

Author information

  • 1Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California, USA.

Abstract

A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.

PMID:
22200772
DOI:
10.1038/ng.1048
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center