Figure 2VB neurone responses before, during and after iontophoretic application of the Group II agonist LY354740 either alone or co-applied with the mGlu2 PAM LY487379 upon short-duration stimulation of the principal vibrissa and execution of the condition–test protocol
Aa, the top three PSTHs represent responses from a single neurone to short-duration stimulation of the principal vibrissa under control conditions, during application of the Group II agonist, and during recovery. The bottom bar graph represents the mean responses of a group of neurones (n = 44) to short-duration stimulation of the principal vibrissa under the same conditions. Ab, the top three PSTHs represent responses from a single neurone upon execution of the condition–test protocol under control conditions, during application of the Group II agonist, and during recovery. The bottom bar graph represents the mean inhibitions of a group of neurones (n = 25) to the condition–test protocol under the same conditions. Ba, the top three PSTHs represent responses from a single neurone to short-duration stimulation of the principal vibrissa under control conditions, upon co-application of the Group II agonist and the mGlu2 PAM and during recovery. The bottom bar graph represents the mean responses of a group of neurones (n = 22) to short-duration stimulation of the principal vibrissa under control conditions, upon application of the Group II agonist alone, and upon co-application of the Group II agonist and the mGlu2 PAM. Bb, the top three PSTHs represent responses from a single neurone to the condition–test protocol under control conditions, during co-application of the Group II agonist and the mGlu2 PAM, and during recovery. The bottom bar graph represents the mean reduction in sensory inhibition of a group of neurones (n = 14) compared to control to application of the Group II agonist alone, or co-applied with the mGlu2 PAM upon execution of the condition–test protocol. T: 20 ms short-duration test stimulation to the principal vibrissa; C: 20 ms conditioning stimulation to a secondary vibrissa; spike count: the total number of action potentials recorded per 2 ms bin over 6 trials. All PSTHs are constructed using responses from the same cell (CVB050b). Bar graph data are expressed as means ± SEM; *P < 0.05.