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Pediatr Infect Dis J. 2012 Apr;31(4):405-7. doi: 10.1097/INF.0b013e3182463a19.

Pharmacokinetic profile of valganciclovir in pediatric transplant recipients.

Author information

1
Infectious Diseases Division, Department of Pediatrics, CHU Sainte-Justine, University of Montréal, Montreal, Quebec, Canada.

Abstract

We evaluated the pharmacokinetic profile of intravenous ganciclovir and oral valganciclovir in transplant children. Median AUC0-24 concentrations obtained after intravenous and oral formulations were 22.9 µg•h/mL (range, 17-65.2) and 34.55 µg•h/mL (range, 20.8-84.2), respectively. After normalization on a 20 mg/kg/d valganciclovir dosage, the median AUC0-24 concentration was 37.6 µg•h/mL (range, 23.6-68).

PMID:
22198827
DOI:
10.1097/INF.0b013e3182463a19
[Indexed for MEDLINE]

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