Send to

Choose Destination
See comment in PubMed Commons below
Free Radic Biol Med. 2012 Feb 15;52(4):757-64. doi: 10.1016/j.freeradbiomed.2011.11.030. Epub 2011 Dec 16.

Activation of the cAMP cascade in human fibroblast cultures rescues the activity of oxidatively damaged complex I.

Author information

Section of Medical Biochemistry, Department of Basic Medical Sciences, University of Bari, Bari, Italy.


A study of the relationship between cAMP/PKA-dependent phosphorylation and oxidative damage of subunits of complex I of the mitochondrial respiratory chain is presented. It is shown that, in fibroblast cultures, PKA-mediated phosphorylation of the NDUFS4 subunit of complex I rescues the activity of the oxidatively damaged complex. Evidence is presented showing that this effect is mediated by phosphorylation-dependent exchange of carbonylated NDUFS4 subunit in the assembled complex with the de novo synthesized subunit. These results indicate a potential use for β-adrenoceptor agonists in preventing/reversing the detrimental effects of oxidative stress in the mitochondrial respiratory system.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center