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Cell. 2011 Dec 23;147(7):1440-1. doi: 10.1016/j.cell.2011.12.001.

Learning to protect your genome on the fly.

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1
Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Piwi-interacting RNAs (piRNAs) help defend host genomes against germline transposons. In this issue of Cell, Khurana et al. show how alterations in the piRNA-encoding loci within a single generation allow a naive fly genome to overcome the initially insurmountable challenge imposed by a newly encountered mobile element.

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