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Cell. 2011 Dec 23;147(7):1438-9. doi: 10.1016/j.cell.2011.12.002.

Transcription and mRNA stability: parental guidance suggested.

Author information

1
Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA. bellofat@umdnj.edu

Abstract

The level of an mRNA within a cell depends on both its rate of synthesis and rate of decay. Now, independent studies by Bregman et al. and Trcek et al. provide evidence that these two processes are integrated. They show that transcription factors and DNA promoters can directly influence the relative stability of transcripts that they produce.

PMID:
22196721
DOI:
10.1016/j.cell.2011.12.002
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