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Mol Cell. 2011 Dec 23;44(6):846-8. doi: 10.1016/j.molcel.2011.12.004.

Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells.

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1
Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK. almut.schulze@cancer.org.uk

Abstract

In this issue of Molecular Cell, Hitosugi et al. (2011) show that the switch from oxidative phosphorylation to glycolysis in cancer cells is regulated by tyrosine phosphorylation of PDHK1.

PMID:
22195959
DOI:
10.1016/j.molcel.2011.12.004
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