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Immunity. 2011 Dec 23;35(6):849-51. doi: 10.1016/j.immuni.2011.12.004.

Necroptosis turns TNF lethal.

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1
INSERM, U848, Villejuif, F-94805, France.

Abstract

In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo.

PMID:
22195740
DOI:
10.1016/j.immuni.2011.12.004
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