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J Antimicrob Chemother. 2012 Mar;67(3):523-9. doi: 10.1093/jac/dkr506. Epub 2011 Dec 22.

Pharmacogenetics of hepatitis C.

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1
Infectious Diseases Department, Hospital Carlos III, Madrid, Spain. vsoriano@dragonet.es

Abstract

Recent discoveries have highlighted the influence of host genomics on hepatitis C virus (HCV) infection outcomes. As a result, our views on hepatitis C pathogenesis and therapeutic approaches have been transformed. The recognition of the impact of single-nucleotide polymorphisms (SNPs) of the genes interleukin 28B (IL28B), inosine triphosphatase (ITPA) and low-density lipoprotein cholesterol receptor (LDLR) may lead to refinements in the pharmacogenomic prediction of antiviral response and drug-related toxicities and favour the discovery of new therapeutic targets for hepatitis C. Although the relevance of host genetics may be less in the setting of very potent new direct-acting antivirals (DAAs), genetic markers may continue to aid decision making regarding the length of therapy. Moreover, in several populations, such as HIV/HCV-coinfected patients, current therapy with peginterferon-α/ribavirin will continue in use for most patients, and thus host factors will retain their predictive value for treatment outcomes for a while.

PMID:
22194301
DOI:
10.1093/jac/dkr506
[Indexed for MEDLINE]
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