Format

Send to

Choose Destination
See comment in PubMed Commons below
Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):40-7. doi: 10.1093/abbs/gmr112.

Genome-wide expression of non-coding RNA and global chromatin modification.

Author information

1
Key Laboratory of Ministry of Education, Department of Molecular Biology, Fudan University, Shanghai, China.

Abstract

Traditionally, we know that genomic DNA will produce transcripts named messenger RNA and then translate into protein following the instruction of genetic central dogma, and RNA works here as a pass-by messenger. Now increasing evidence shows that RNA is a key regulator as well as a message transmitter. It is discovered by next-generation sequencing techniques that most genomic DNA are generally transcribed to non-coding RNA, highly beyond the percentage of coding mRNA. These non-coding RNAs (ncRNAs), belonging to several groups, have critical roles in many cellular processes, expanding our understanding of the RNA world. We review here the different categories of ncRNA according to genome location and how ncRNAs guide and recruit chromatin modification complex to specific loci of genome to modulate gene expression by affecting chromatin state.

PMID:
22194012
DOI:
10.1093/abbs/gmr112
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center