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Nanoscale. 2012 Apr 21;4(8):2575-9. doi: 10.1039/c2nr11502f. Epub 2011 Dec 22.

Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent.

Author information

1
Centre for Strategic Nano-Fabrication, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia.

Abstract

Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.

PMID:
22193941
DOI:
10.1039/c2nr11502f
[Indexed for MEDLINE]

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