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Nat Cell Biol. 2011 Dec 22;14(1):38-45. doi: 10.1038/ncb2381.

Shaping development with ESCRTs.

Author information

1
Centre for Cancer Biomedicine, Oslo University Hospital, Montebello, 0310 Oslo, Norway.

Abstract

Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.

PMID:
22193162
DOI:
10.1038/ncb2381
[Indexed for MEDLINE]

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