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Nat Cell Biol. 2011 Dec 22;14(1):2-10. doi: 10.1038/ncb2403.

Lessons from yeast for clathrin-mediated endocytosis.

Author information

1
Department of Molecular and Cellular Pharmacology (R-189), Miller School of Medicine, University of Miami, Miami, Florida 33101, USA.

Abstract

Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

PMID:
22193158
PMCID:
PMC5590828
DOI:
10.1038/ncb2403
[Indexed for MEDLINE]
Free PMC Article

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