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Arthritis Res Ther. 2011;13(6):250. doi: 10.1186/ar3528. Epub 2011 Dec 21.

Mechanisms of tissue injury in lupus nephritis.

Author information

1
Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 912 MSC 637 Charleston, SC 29425-6370, USA.

Abstract

Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.

PMID:
22192660
PMCID:
PMC3334648
DOI:
10.1186/ar3528
[Indexed for MEDLINE]
Free PMC Article

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