Format

Send to

Choose Destination
See comment in PubMed Commons below
Assay Drug Dev Technol. 2012 Jun;10(3):269-77. doi: 10.1089/adt.2011.0421. Epub 2011 Dec 22.

A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.

Author information

1
Department of Chemistry, Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Abstract

An oxetane-substituted sulfoxide has demonstrated potential as a dimethylsulfoxide substitute for enhancing the dissolution of organic compounds with poor aqueous solubilities. This sulfoxide may find utility in applications of library storage and biological assays. For the model compounds studied, significant solubility enhancements were observed using the sulfoxide as a cosolvent in aqueous media. Brine shrimp, breast cancer (MDA-MB-231), and liver cell line (HepG2) toxicity data for the new additive are also presented, in addition to comparative IC(50) values for a series of PKD1 inhibitors.

PMID:
22192308
PMCID:
PMC3374385
DOI:
10.1089/adt.2011.0421
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc. Icon for PubMed Central
    Loading ...
    Support Center