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Fertil Steril. 2012 Jan;97(1):7-12. doi: 10.1016/j.fertnstert.2011.11.023.

Is PCOS an inflammatory process?

Author information

1
Department of Obstetrics and Gynecology, University of California Davis, Sacramento, California 95817, USA. ajduleba@ucdavis.edu

Abstract

PRO--PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood cell count as well as endothelial dysfunction and increased oxidative stress. CON--Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneous for the diagnosis, confounded by degree of adiposity and do not consistently demonstrate a clinically relevant increase in the above mentioned biomarkers.

PMID:
22192135
PMCID:
PMC3245829
DOI:
10.1016/j.fertnstert.2011.11.023
[Indexed for MEDLINE]
Free PMC Article

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