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Clin Dev Immunol. 2011;2011:842849. doi: 10.1155/2011/842849. Epub 2011 Nov 30.

The roles of tumor-derived exosomes in cancer pathogenesis.

Author information

1
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

Abstract

Exosomes are endosome-derived, 30-100 nm small membrane vesicles released by most cell types including tumor cells. They are enriched in a selective repertoire of proteins and nucleic acids from parental cells and are thought to be actively involved in conferring intercellular signals. Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses. However, tumor-derived exosomes also have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance. These different effects of tumor-derived exosomes contribute to the pathogenesis of cancer. This review will discuss the roles of tumor-derived exosomes in cancer pathogenesis, therapy, and diagnostics.

PMID:
22190973
PMCID:
PMC3235485
DOI:
10.1155/2011/842849
[Indexed for MEDLINE]
Free PMC Article

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