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Infect Dis Obstet Gynecol. 2011;2011:216217. doi: 10.1155/2011/216217. Epub 2011 Dec 8.

Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy.

Author information

1
Department of Family & Preventive Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. amlang@emory.edu

Abstract

OBJECTIVE:

To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy.

METHODS:

Biospecimens and data were derived from a random sample (N = 160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score ≥7) and assessed the odds of BV for those with 25-OH-D <12 ng/mL, folate <5 ug/L, and omega-6/omega-3 ratio >15.

RESULTS:

The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00±8.14 ng/mL versus 24.34±11.97 ng/mL, P = 0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12 ng/mL (aOR 5.11, 95% CI: 1.19-21.97) and folate <5 ug/L (aOR 7.06, 95% CI: 1.07-54.05).

CONCLUSION:

Vitamin D and folate deficiencies were strongly associated with BV (Nugent score ≥7) during pregnancy.

PMID:
22190843
PMCID:
PMC3235789
DOI:
10.1155/2011/216217
[Indexed for MEDLINE]
Free PMC Article

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