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J Maxillofac Oral Surg. 2010 Jun;9(2):213-7. doi: 10.1007/s12663-010-0054-3. Epub 2010 Sep 22.

A case of oral multiple primary cancer including Spindle Cell Carcinoma.


Spindle Cell Carcinoma (SPCC) is a relatively rare tumour that is classified as a subtype of squamous cell carcinoma (SCC). Histologically, SPCC is composed of a SCC region and epithelium-derived spindle cells with mesenchymal differentiation. We encountered an interesting case of multiple cancer including SPCC. A histopathologically atypical papillary lesion was found 13 years before our initial examination. Multiple verrucous leukoplakia later developed in the oral mucosa, for which an oral vitamin A derivative (a retinoid) was intermittently administered. Multiple cancer including SPCC subsequently developed in the lower gingiva. We investigated the case histologically and immunohistologically based on the concept of field cancerization.


Field cancerization; Multiple cancer; Retinoid; Spindle cell carcinoma; Squamous cell carcinoma

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