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J Biochem Mol Toxicol. 2011 Nov-Dec;25(6):404-8. doi: 10.1002/jbt.20396.

Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis.

Author information

1
Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China.

Abstract

microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. However, the mechanism of miR-195 action is not completely understood. This review summarizes recent the research progress regarding the roles of miR-195 in the cell cycle and in apoptosis.

PMID:
22190509
DOI:
10.1002/jbt.20396
[Indexed for MEDLINE]

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