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Genes Dev. 2011 Dec 15;25(24):2555-8. doi: 10.1101/gad.183020.111.

A new 'Linc' between noncoding RNAs and blood development.

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1
Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.

PMID:
22190456
PMCID:
PMC3248677
DOI:
10.1101/gad.183020.111
[Indexed for MEDLINE]
Free PMC Article
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