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J Sci Food Agric. 2012 May;92(7):1570-2. doi: 10.1002/jsfa.5544. Epub 2011 Dec 20.

Aloysia triphylla infusion protects rats against dextran sulfate sodium-induced colonic damage.

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1
Laboratoire de Pharmacognosie et Phytothérapie, Clermont Université, Université d'Auvergne, EA 4233, Clermont-Ferrand, France.

Abstract

BACKGROUND:

Inflammatory bowel diseases consist of uncontrolled intestinal inflammation leading to mucosal disruption. Polyphenols are micronutrients with antioxidant and anti-inflammatory properties and may play an interesting role in the prevention of intestinal inflammation. Lemon verbena (Aloysia triphylla (L'Herit.) Britton, Verbenaceae) infusion is a popular herbal drink rich in polyphenols. This study evaluated the protective effects of lemon verbena infusion consumption on the development of dextran sulfate sodium (DSS)-induced colitis in rats. The infusion was given to rats as a drink providing 82 µmol polyphenols day(-1) for 21 days. Colitis was induced with 40 g l(-1) DSS in the drink for the last 7 days.

RESULTS:

Lemon verbena infusion treatment restored body weight gain and prevented colonic shortening. Despite no protective effect on myeloperoxidase activity, A. triphylla infusion limited histological colonic alterations.

CONCLUSION:

The results suggest that lemon verbena infusion partially protects rats against DSS-induced inflammation.

PMID:
22190244
DOI:
10.1002/jsfa.5544
[Indexed for MEDLINE]

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