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J Dig Dis. 2012 Jan;13(1):2-9. doi: 10.1111/j.1751-2980.2011.00550.x.

The gastric precancerous cascade.

Author information

1
Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0252, USA. pelayo.correa@vanderbilt.edu

Abstract

Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first "complete" and then "incomplete"); dysplasia, first low grade and then high grade (equivalent to "carcinoma in situ"). The following step is invasive carcinoma, which is thought to be associated with degradation of the intercellular matrix.

PMID:
22188910
PMCID:
PMC3404600
DOI:
10.1111/j.1751-2980.2011.00550.x
[Indexed for MEDLINE]
Free PMC Article
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