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Biotechnol Lett. 2012 Apr;34(4):717-20. doi: 10.1007/s10529-011-0827-x. Epub 2011 Dec 21.

Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison.

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Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaußstrasse 17, 38106, Braunschweig, Germany.


Violacein and deoxyviolacein display a broad range of interesting biological properties but their production is rarely distinguished due to the lack of suitable analytical methods. An HPLC method has been developed for the separation and quantification of violacein and deoxyviolacein and can determine the content of both molecules in microbial cultures. A comparison of different production microorganisms, including recombinant Escherichia coli and the natural producer Janthinobacterium lividum, revealed that the formation of violacein and deoxyviolacein is strain-specific but showed significant variation during growth although the ratio between the two compounds remained constant.

[Indexed for MEDLINE]

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