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EMBO J. 2012 Feb 15;31(4):805-16. doi: 10.1038/emboj.2011.453. Epub 2011 Dec 20.

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases.

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1
Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

Abstract

Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses in the hippocampus is mediated by Src family kinase regulation of NMDA receptors (NMDARs). We found that stimulation of G-protein-coupled receptors (GPCRs) regulated the absolute contribution of GluN2A-versus GluN2B-containing NMDARs in CA1 neurons: pituitary adenylate cyclase activating peptide 1 receptors (PAC1Rs) selectively recruited Src kinase, phosphorylated GluN2ARs, and enhanced their functional contribution; dopamine 1 receptors (D1Rs) selectively stimulated Fyn kinase, phosphorylated GluN2BRs, and enhanced these currents. Surprisingly, PAC1R lowered the threshold for long-term potentiation while long-term depression was enhanced by D1R. We conclude that metaplasticity is gated by the activity of GPCRs, which selectively target subtypes of NMDARs via Src kinases.

PMID:
22187052
PMCID:
PMC3280552
DOI:
10.1038/emboj.2011.453
[Indexed for MEDLINE]
Free PMC Article
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