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J Cereb Blood Flow Metab. 2012 Mar;32(3):443-6. doi: 10.1038/jcbfm.2011.184. Epub 2011 Dec 21.

Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study.

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  • 1Vivian M Rakoff PET Imaging Centre, Toronto, Canada.

Abstract

Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [(11)C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A V(T), an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa-levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.

PMID:
22186668
PMCID:
PMC3293124
DOI:
10.1038/jcbfm.2011.184
[PubMed - indexed for MEDLINE]
Free PMC Article
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