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Curr Opin Organ Transplant. 2012 Feb;17(1):100-5. doi: 10.1097/MOT.0b013e32834ee700.

Long-term outcome after pancreas transplantation.

Author information

1
College of Public Health, University of Arizona, 1295 N. Martin Ave, Tucson, AZ 85724-5163, USA. acgruess@email.arizona.edu

Abstract

PURPOSE OF REVIEW:

Pancreas transplantation provides the only proven method to restore long-term normoglycemia in patients with insulin-dependent diabetes mellitus. Although many studies describe the very important risk factors for short-term survival of a pancreas transplant, there is not a lot of information available about factors that distinguish short-term from long-term graft function.

RECENT FINDINGS:

The analysis of 18,159 pancreas transplants from the International Pancreas Transplant Registry, performed from 25 July 1978 to 31 December 2005, showed an improvement not only in short-term but also in long-term graft function. Most recent 5-year, 10-year and 20-year graft function for transplants with the appropriate follow-up time showed 80, 68 and 45%, respectively, for simultaneous pancreas/kidney transplants; 62, 46 and 16%, respectively, for pancreas after kidney; and 59, 39 and 12%, respectively, for pancreas transplants alone. Important factors influencing long-term function were factors that described the quality of the deceased donor. Pancreas transplants in younger or African-American recipients showed a higher risk of graft failure. Anti-T-cell induction therapy had a significant impact on long-term survival in solitary transplants.

SUMMARY:

With a careful donor selection, not only short-term but also long-term pancreas graft function and, therefore, good metabolic control can be achieved for the diabetic patient.

PMID:
22186094
DOI:
10.1097/MOT.0b013e32834ee700
[Indexed for MEDLINE]

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