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ACS Chem Biol. 2012 Jan 20;7(1):73-86. doi: 10.1021/cb200447r. Epub 2012 Jan 12.

Recent advances in developing small molecules targeting RNA.

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Department of Chemistry, The Kellogg School of Science and Technology, The Scripps Research Institute, Scripps Florida, Jupiter, 33458, United States.


RNAs are underexploited targets for small molecule drugs or chemical probes of function. This may be due, in part, to a fundamental lack of understanding of the types of small molecules that bind RNA specifically and the types of RNA motifs that specifically bind small molecules. In this review, we describe recent advances in the development and design of small molecules that bind to RNA and modulate function that aim to fill this void.

[Indexed for MEDLINE]

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