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Nat Rev Neurosci. 2011 Dec 20;13(1):7-21. doi: 10.1038/nrn3125.

Nanodomain coupling between Ca²⁺ channels and sensors of exocytosis at fast mammalian synapses.

Author information

1
IST Austria (Institute of Science and Technology Austria), Am Campus 1, A-3400 Klosterneuburg, Austria.

Abstract

The physical distance between presynaptic Ca(2+) channels and the Ca(2+) sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca(2+) channels that are coupled to Ca(2+) sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein-protein interactions involving Ca(2+) channels, Ca(2+) sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission.

PMID:
22183436
PMCID:
PMC3617475
DOI:
10.1038/nrn3125
[Indexed for MEDLINE]
Free PMC Article

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