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Cardiol Rev. 2012 Mar-Apr;20(2):72-6. doi: 10.1097/CRD.0b013e31823c808b.

Cardiac manifestations of neonatal lupus: a review of autoantibody-associated congenital heart block and its impact in an adult population.

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1
Department of Pediatrics, Children's Hospital of Montefiore, Bronx, NY, USA.

Abstract

Within the last decade the prevalence of adult patients living with congenital heart disease equals that seen in children. This expanding population poses a challenge to clinical cardiologists who will be caring for patients with the clinical manifestations of this condition. Neonatal lupus is a model of passively acquired autoimmunity and is responsible for the majority of clinical cases of congenital heart block (CHB). This review will focus on the presentation, pathophysiology, and the long-term follow-up of CHB associated with neonatal lupus, and discuss important diagnostic tests, familial implications, and pacemaker issues associated with the care of an adult with CHB.

PMID:
22183063
PMCID:
PMC3275696
DOI:
10.1097/CRD.0b013e31823c808b
[Indexed for MEDLINE]
Free PMC Article
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