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Neurobiol Dis. 2012 May;46(2):255-62. doi: 10.1016/j.nbd.2011.12.008. Epub 2011 Dec 13.

Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease.

Author information

1
The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA. dgavin@psych.uic.edu

Abstract

Cortical and subcortical dysfunction in schizophrenia includes altered expression of RNA and proteins involved in neurotransmission, metabolism, myelination and other functions. The molecular mechanisms underlying this type of alteration remain largely unknown. Here, we summarize findings from postmortem brain studies and argue that transcriptional dysregulation, including changes in DNA and histone modifications involved in epigenetic control of gene expression, as well as microRNA-mediated post-transcriptional mechanisms contribute to the neurobiology of schizophrenia.

PMID:
22182689
DOI:
10.1016/j.nbd.2011.12.008
[Indexed for MEDLINE]

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