Send to

Choose Destination
See comment in PubMed Commons below
Acta Paediatr. 2012 May;101(5):e208-12. doi: 10.1111/j.1651-2227.2011.02569.x. Epub 2012 Jan 10.

Astrovirus and digestive disorders in neonatal units.

Author information

Department of Pediatrics CHU Rennes, Rennes, France.



To describe clinical signs associated with Human Astrovirus (HAstV) in stools in neonatal units.


During 2005-2006, all stool virology performed for isolated digestive symptoms or suspicion of neonatal infection was tested for HAstV by an amplified enzyme-linked immunoassay (IDEIA™ Astrovirus test, Dako Cytomation). Each newborn with a positive result (HAstV+ group) was retrospectively matched with the first following symptomatic newborn in the same care unit having a negative stool virology (HAstV- group). Clinical data were collected during two 3-day periods (just after faecal samples collection and 1 week before) and compared within and between each group.


Human astrovirus was detected in faeces of 68 newborns [gestational age: 31.4(28.8-34) weeks] at a post-natal age of 23 (15-42) days without seasonal dominance. Human astrovirus+ and HAstV- groups were comparable. Bloody stool (54.4% versus 14.7%, p < 0.01) and stage II-III necrotizing enterocolitis (20.6% versus 4.4%, p < 0.05) were more frequently observed in HAstV+ than in HAstV- group; these associations were confirmed by logistic regression analysis.


This descriptive study argues for a possible association between HAstV and digestive symptoms in newborns specifically in preterm infants.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center