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Bratisl Lek Listy. 2011;112(11):603-4.

Effects of atorvastatin on heart mitochondrial function and coenzyme Q content in the experiment.

Author information

1
Pharmacobiochemical Laboratory of Third Department of lnternal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia. jarmila.kucharska@fmed.uniba.sk

Abstract

We focused on determination of whether atorvastatin: 1) reduces CoQ content, 2) impairs mitochondrial function and 3) induces dose-dependent changes. Although the high dose of atorvastatin exerted a beneficial effect on the lipid peroxidation in plasma, coenzyme Q content was reduced and heart mitochondrial function was impaired. Physicians should be aware when prescribing statins mainly in higher doses to the patients with co-existing proved or supposed CoQ10 deficiency resulting from age-related decline, and metabolic or mitochondrial diseases (Ref. 3).

PMID:
22180983
[Indexed for MEDLINE]

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