Send to

Choose Destination
Drug Discov Today. 2012 Feb;17 Suppl:S31-44. doi: 10.1016/j.drudis.2011.12.007. Epub 2011 Dec 10.

Drug discovery in the next decade: innovation needed ASAP.

Author information

Vertex Pharmaceuticals, 130 Waverly St., Cambridge, MA 02139, USA.


Pharmaceutical companies must find a better way to increase their output of truly new drugs for the benefit of patients and for their business survival. Here, I highlight a general perspective from within pharmaceutical research as it pertains to research advances in chemistry, biology, pharmacology, pharmacokinetics and toxicology that, if well integrated, stands to put the industry on a productive path. In addition, I provide a complementary perspective on the corporate culture aspect of innovation. I also introduce a new concept, termed 'innovation ASAP' (iASAP; asking powerful questions, seeking the outliers, accepting defeat and populating astutely) and provide support for it using examples of several successful drugs.

Republished from

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center