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Curr Opin Genet Dev. 2012 Apr;22(2):139-47. doi: 10.1016/j.gde.2011.11.005. Epub 2011 Dec 16.

Structure, assembly and reading of centromeric chromatin.

Author information

1
Institute for Research in Immunology and Cancer, Dept of Pathology and Cell Biology, Université de Montréal, Montréal, QC H3C 3J7, Canada. paul.maddox@umontreal.ca

Abstract

Centromeres are epigenetically defined chromatin domains marked by the presence of the histone H3 variant CENP-A. Here we review recent structural and biochemical work on CENP-A, and advances in understanding the mechanisms that propagate and read centromeric chromatin domains.

PMID:
22178421
PMCID:
PMC3319190
DOI:
10.1016/j.gde.2011.11.005
[Indexed for MEDLINE]
Free PMC Article

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