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Maturitas. 2012 Feb;71(2):162-8. doi: 10.1016/j.maturitas.2011.11.020. Epub 2011 Dec 16.

Should risk of bone fragility restrict weight control for other health reasons in postmenopausal women?--A ten year prospective study.

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1
University of Eastern Finland, Bone and Cartilage Research Unit (BCRU), Kuopio, Finland. joonas.sirola@kuh.fi

Abstract

BACKGROUND:

The aim of the present study was to investigate the health risks of excess body weight in the light of its protective effects on bone fragility.

METHODS:

Femoral neck and lumbar spine dual X-ray absorptiometry was performed for 1970 Finnish women with a mean baseline age of 58.8 years (range 53.1-65.7 years) in 1994 and 2004. Women were categorized according to baseline BMI into normal <25 kg/m2, overweight 25-29.9 kg/m(2) and obese ≥30 kg/m(2). Weight change (kg) was categorized into tertiles. Co-morbidities, not allowed to be present at baseline, was based on self-reports. Osteoporosis was defined as femoral neck or spinal (L2-L4) T-score <-2.5 SD at 10-year follow-up or <-2.0 SD+low trauma energy follow-up fracture. Uni- and multivariate logistic regression models were used to estimate the 10-year risk of incident health disorders. Adjustment for age, number of diseases, alcohol intake and smoking was used in the multivariate models.

RESULTS:

Obesity (Ob) and overweight (Ow) were related with higher 10-year risk of hypertension (OR=2.6 (Ob)/OR=1.7 (Ow), p<0.001), coronary artery disease (OR=1.6, p<0.05/OR=1.2, p=NS), diabetes (OR=11.7/OR=5.3, p<0.001), osteoarthritis (OR=1.4, p<0.05/OR=1.1, p=NS), chronic back pain (OR=1.6, p=0.007/OR=1.2, p=NS) and poor self-rated health (OR=2.4, p<0.05/OR=1.5, p=NS) and lower risk of osteoporosis (OR=0.13/OR=0.28, p<0.001). Weight change of less than +1 kg was associated 1.8 and 2.6 times lower 10-year risk of having hypertension and breast cancer than weight change over 6.2 kg. Among obese women the absolute risk increase of hypertension was 17%, of diabetes 12%, and absolute risk reduction of osteoporosis 14% in comparison to BMI <25 kg/m(2).

CONCLUSIONS:

Health related risks of high BMI outweigh its protective effects on bone. Weight gain increases the risk hypertension and breast cancer.

PMID:
22177977
DOI:
10.1016/j.maturitas.2011.11.020
[Indexed for MEDLINE]
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