Format

Send to

Choose Destination
Virology. 2012 Feb 5;423(1):1-5. doi: 10.1016/j.virol.2011.11.016. Epub 2011 Dec 15.

Drosophila as a genetic model for studying pathogenic human viruses.

Author information

1
Department of Natural Sciences, Northeastern State University, Tahlequah, OK 74464, USA.

Abstract

Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.

PMID:
22177780
PMCID:
PMC3253880
DOI:
10.1016/j.virol.2011.11.016
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center