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Fertil Steril. 2012 Feb;97(2):391-4. doi: 10.1016/j.fertnstert.2011.11.025. Epub 2011 Dec 16.

Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities.

Author information

1
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, People's Republic of China.

Abstract

OBJECTIVE:

To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs).

DESIGN:

Phenotypic and mutational study.

SETTING:

University hospital.

PATIENT(S):

A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals.

INTERVENTION(S):

Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants.

MAIN OUTCOME MEASURE(S):

Not applicable.

RESULT(S):

The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs).

CONCLUSION(S):

The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.

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