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Am J Transplant. 2012 Apr;12(4):812-9. doi: 10.1111/j.1600-6143.2011.03873.x. Epub 2011 Dec 17.

Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.

Author information

1
Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. leslie.kean@emory.edu

Abstract

Nonhuman primate (NHP) models play a critical role in the translation of novel therapies for transplantation to the clinic. However, although MHC disparity significantly affects the outcome of transplantation, until recently, experiments using NHP models were performed without the ability to rigorously control the degree of MHC disparity in transplant cohorts. In this review, we discuss several key technical breakthroughs in the field, which have finally enabled detailed immunogenetic data to be incorporated into NHP transplantation studies. These advances have created a new gold-standard for NHP transplantation research, which incorporates detailed information regarding the degree of relatedness and the degree of MHC haplotype disparity between transplant pairs and the precise MHC alleles that both donors and recipients express. The adoption of this new standard promises to increase the rigor of NHP transplantation studies and to ensure that these experiments are optimally translatable to patient care.

PMID:
22177005
PMCID:
PMC3482466
DOI:
10.1111/j.1600-6143.2011.03873.x
[Indexed for MEDLINE]
Free PMC Article
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