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Transpl Infect Dis. 2012 Jun;14(3):300-4. doi: 10.1111/j.1399-3062.2011.00696.x. Epub 2011 Dec 18.

Donor-derived organ transplant transmission of coccidioidomycosis.

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1
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin.

PMID:
22176496
PMCID:
PMC4659351
DOI:
10.1111/j.1399-3062.2011.00696.x
[Indexed for MEDLINE]
Free PMC Article
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