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Indian J Nucl Med. 2011 Apr;26(2):86-90. doi: 10.4103/0972-3919.90258.

Radiation exposure to nuclear medicine personnel handling positron emitters from Ge-68/Ga-68 generator.

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1
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Abstract

OBJECTIVE:

To measure the radiation exposure to nuclear medicine personnel during synthesis and injection to the patients of Ga-68 1,4,7,10-tetraazacyclododecane-N,N',N″,N″'-tetraacetic acid (DOTA)-1-Nal(3)-octreotide (NOC)- (DOTA-NOC) using ring thermoluminescence dosimeters (TLDs).

MATERIALS AND METHODS:

Synthesis of Ga-68 DOTA-NOC was done on a semi-automated system. Finger doses were measured during synthesis and injection of Ga-68 DOTA-NOC. The occupational workers wore TLDs at the base of ring finger of both hands. The finger doses of two radio chemists were measured during synthesis of Ga-68 DOTA-NOC while that of a physician during its injection to the patients.

RESULTS:

Duration of the study was eight months and a total of 20 samples were prepared. During synthesis, the mean dose to base of left ring finger was 3.02 ± 1.01 mSv and to base of right ring finger was 1.96 ± 0.86 mSv. Mean dose to base of left ring finger was 1.26 ± 0.35 mSv while that to base of right ring finger was 1.03 ± 0.13 mSv during injection. The mean dose was observed to be higher during synthesis than injection. However, the difference was not significant (P = 0.27 and P = 0.18, respectively). Overall mean finger dose of left hand was 2.43 ± 1.21 mSv, whereas for the right hand the same was 1.65± 0.82 mSv.

CONCLUSION:

Finger doses to radio chemists during semi-automated synthesis of Ga-68 DOTA-NOC and that to the physician involved in injection of Ga-68 DOTA-NOC were found to be within permissible limits. Ring dosimeters must be worn for the safety of the nuclear medicine personnel involved in synthesis and injection of Ga-68 DOTA-NOC.

KEYWORDS:

Ga-68 DOTA-NOC; TLD; radiation dose; ring dosimeter

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