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Cephalalgia. 2012 Jan;32(2):140-9. doi: 10.1177/0333102411431333. Epub 2011 Dec 15.

Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers.

Author information

1
University of Copenhagen, Denmark.

Abstract

AIM:

To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).

METHODS:

In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).

RESULTS:

We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).

CONCLUSION:

PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.

PMID:
22174350
DOI:
10.1177/0333102411431333
[Indexed for MEDLINE]

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