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Int J STD AIDS. 2011 Dec;22(12):695-708. doi: 10.1258/ijsa.2011.171011.

UK guideline for the use of post-exposure prophylaxis for HIV following sexual exposure (2011).

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  • 1Camden Provider Services, Central and North West London NHS Foundation Trust, London.


We present the updated British Association for Sexual Health and HIV (BASHH) guidelines for post-exposure prophylaxis (PEPSE) to HIV. This document includes a review of the current data to support the use of PEPSE, considers how to calculate the risks of infection after a potential exposure, and provides recommendations on when PEPSE would and would not be considered. We review which agents to use for PEPSE including the potential for drug-drug interactions and make recommendations for monitoring individuals receiving PEPSE. Other areas included are the possible impact on sexual behaviour, cost-effectiveness and issues relating to service provision. Throughout the document, consideration is given to the place of PEPSE within the broader context of HIV prevention strategies and sexual health.

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