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Pediatr Infect Dis J. 2012 Apr;31(4):413-4. doi: 10.1097/INF.0b013e318242534a.

Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis.

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1
Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University, Nashville, TN, USA.

Abstract

Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in premature infants and has been linked with viral antigens in as much as 40% of cases in single-center cohorts. We examined 28 tissue sections from surgically resected ileum from 27 preterm infants with NEC from 2 separate institutions for 15 common bacterial, viral, and parasitic gastrointestinal pathogens using multiplex reverse transcriptase polymerase chain reaction amplification and suspension array detection methods. We did not detect infectious enteritis pathogens in any of the NEC tissues and conclude that gastrointestinal pathogens are a rare cause of NEC.

PMID:
22173144
PMCID:
PMC3305842
DOI:
10.1097/INF.0b013e318242534a
[Indexed for MEDLINE]
Free PMC Article
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