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Dev Cell. 2011 Dec 13;21(6):979-80. doi: 10.1016/j.devcel.2011.11.010.

Tracking intron removal in real time.

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Department of Medicine, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.


Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reported single-molecule analyses of pre-mRNA splicing, confirming transcription-coupled splicing of constitutive introns but finding off-site and delayed splicing of alternative introns. The results raise the question of whether kinetics distinguishes constitutive from regulated splicing.

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