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Curr Opin Microbiol. 2012 Apr;15(2):118-24. doi: 10.1016/j.mib.2011.11.009. Epub 2011 Dec 13.

Histidine kinases and response regulators in networks.

Author information

1
Munich Center for integrated Protein Science at the Ludwig-Maximilians-Universität München, Department of Biology I, Microbiology, Großhaderner Str. 2-4, 82152 Martinsried, Germany. jung@lmu.de

Abstract

Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how accessory proteins are employed by HKs and RRs to mediate signal integration, scaffolding, interconnection and allosteric regulation, and how these two components are embedded in regulatory networks.

PMID:
22172627
DOI:
10.1016/j.mib.2011.11.009
[Indexed for MEDLINE]

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